Xun Bao Selected Research

Hydroxymethyl and Formyl Transferases

2/2024	Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer.
1/2021	Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

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Xun Bao Research Topics

Disease

21	Neoplasms (Cancer) 12/2023 - 04/2016
9	Brain Neoplasms (Brain Tumor) 12/2022 - 08/2016
5	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 08/2016
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2023 - 11/2022
4	Breast Neoplasms (Breast Cancer) 01/2022 - 04/2016
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 04/2016
3	Triple Negative Breast Neoplasms 01/2019 - 04/2016
2	Leukemia 12/2023 - 04/2023
2	Hereditary Neoplastic Syndromes (Cancer Syndrome, Hereditary) 01/2022 - 01/2018
2	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2021
1	Ovarian Epithelial Carcinoma 02/2024
1	Ovarian Neoplasms (Ovarian Cancer) 02/2024
1	Non-alcoholic Fatty Liver Disease 02/2024
1	Inflammation (Inflammations) 02/2024
1	Fibrosis (Cirrhosis) 02/2024
1	Fatty Liver 02/2024
1	Glioma (Gliomas) 12/2022
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2022
1	Neoplasm Micrometastasis 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 12/2018

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2016
4	EnzymesIBA 01/2022 - 01/2018
4	Succinic Acid (Succinate)IBA 01/2022 - 01/2018
4	FumaratesIBA 01/2022 - 01/2018
3	venetoclaxIBA 12/2023 - 04/2023
3	Fumarate Hydratase (Fumarase)IBA 01/2022 - 01/2018
3	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2022 - 01/2018
3	ribociclibIBA 01/2021 - 03/2019
2	Hydroxymethyl and Formyl TransferasesIBA 02/2024 - 01/2021
2	Serine (L-Serine)FDA Link 02/2024 - 02/2024
2	CarbonIBA 02/2024 - 01/2021
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 02/2024 - 10/2019
2	ME-344IBA 12/2023 - 04/2023
2	IsoflavonesIBA 12/2023 - 04/2023
2	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2023 - 04/2023
2	pamiparibIBA 12/2022 - 01/2022
2	ceritinibIBA 01/2022 - 02/2018
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022 - 01/2018
2	Phosphotransferases (Kinase)IBA 01/2022 - 08/2016
2	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2021 - 01/2020
2	Adenosine Triphosphatases (ATPase)IBA 01/2021 - 01/2020
2	pyrimidineIBA 01/2021 - 01/2019
2	alpha-hydroxyglutarateIBA 01/2020 - 01/2019
2	DNA (Deoxyribonucleic Acid)IBA 10/2019 - 01/2018
2	GoldIBA 01/2019 - 04/2016
2	adavosertibIBA 12/2017 - 08/2016
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 02/2024
1	Cisplatin (Platino)FDA LinkGeneric 02/2024
1	CholesterolIBA 02/2024
1	FructoseIBA 02/2024
1	Azacitidine (5 Azacytidine)FDA Link 10/2023
1	neratinibIBA 01/2022
1	tucatinibIBA 01/2022
1	2- (1- (3- dimethylaminopropyl)- 5- methoxyindol- 3- yl)- 3- (1H- indol- 3- yl)maleimideIBA 01/2022
1	3- (2,4- dichloro- 5- methoxyphenyl)- 2- sulfanyl- 4(3H)- quinazolinoneIBA 01/2022
1	Lapatinib (GW572016)FDA Link 01/2022
1	Tyrosine Kinase InhibitorsIBA 01/2022
1	Insulin-Like PeptidesIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	GadoliniumIBA 01/2022
1	Retinaldehyde (Retinal)IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Dynamins (Dynamin)IBA 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2022
1	abemaciclibIBA 01/2021
1	palbociclibIBA 01/2021
1	Cyclin DIBA 01/2021
1	RibonucleotidesIBA 01/2021
1	NucleotidesIBA 01/2021
1	Large Neutral Amino Acid-Transporter 1IBA 01/2021
1	ThiophenesIBA 01/2021
1	Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)IBA 01/2021
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021
1	purineIBA 01/2021
1	Cyclin-Dependent Kinase 4IBA 01/2021
1	glycinamide ribonucleotideIBA 01/2021
1	furanIBA 01/2021
1	isocitric acid (isocitrate)IBA 01/2020
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2020
1	SodiumIBA 01/2020
1	Claudin-5IBA 01/2020
1	Retinoblastoma ProteinIBA 10/2019
1	MTOR InhibitorsIBA 10/2019
1	Adenosine Triphosphate (ATP)IBA 10/2019
1	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 10/2019
1	NAD (NADH)IBA 10/2019
1	acetonitrileIBA 03/2019
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 03/2019
1	Amino Acids FDA Link 01/2019
1	Purine NucleosidesIBA 01/2019
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2019
1	Topoisomerase I InhibitorsIBA 01/2019
1	A-Form DNA (A-DNA)IBA 01/2019
1	enzalutamideIBA 12/2018
1	Testosterone (Sustanon)FDA Link 12/2018
1	Androgen Receptors (Androgen Receptor)IBA 12/2018
1	Hormones (Hormone)IBA 12/2018

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 12/2023 - 01/2021
5	Therapeutics 12/2023 - 12/2018